The New England Patriots will host the Indianapolis Colts in a pivotal Week 9 matchup for both teams.
The losing side will face a tough, uphill climb toward the AFC playoffs.
Injuries could play a key role in the outcome of Sunday's game.
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The Patriots had four players -- center David Andrews, running back Damien Harris, safety Devin McCourty and wide receiver DeVante Parker -- miss practice Wednesday.
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Andrews suffered a concussion in the Week 7 loss to the Chicago Bears and didn't play in the Week 8 victory over the New York Jets. Harris returned to the lineup in Week 8 after not playing against the Bears. Parker played only one snap against the Jets.
New England Patriots
McCourty didn't miss practice due to injury. It was a planned off day to help keep the 35-year-old defensive back fresh.
The Colts also had a few important players miss Wednesday's practice, including star running back Jonathan Taylor and cornerback Stephon Gilmore.
Here's the first Week 9 injury report for the Patriots and Colts.
New England Patriots (4-4)
DID NOT PARTICIPATE
- C David Andrews - Concussion
- RB Damien Harris - Illness
- S Devin McCourty - Not Injury Related
- WR DeVante Parker - Knee
LIMITED PARTICIPATION
- DL Christian Barmore - Knee
- S Kyle Dugger - Ankle
- S Adrian Phillips - Shoulder
- WR/ SPT - Matthew Slater - Hamstring
- RB Pierre Strong Jr. - Hamstring
- LB Josh Uche - Hamstring
- DE Deatrich Wise Jr. - Ankle
FULL PARTICIPATION
- No players listed
Indianapolis Colts (3-4-1)
DID NOT PARTICIPATE
- CB Tony Brown - Hamstring
- CB Stephon Gilmore - Rib
- T Dennis Kelly - Calf/Ankle
- RB Zack Moss - Not Injury Related - Travel
- DE Yannick Ngakoue - Not Injury Related - Resting Player
- QB Matt Ryan - Right Shoulder
- LB Grant Stuard - Pectoral
- RB Jonathan Taylor - Ankle
LIMITED PARTICIPATION
- C Ryan Kelly - Knee
- DE Kwity Paye - Ankle
FULL PARTICIPATION
- DT DeForest Buckner - Shoulder
- LB E.J. Speed - Ankle